KROK 1 2018 – Question 163 · KROK (Medicine) · Biological Chemistry
A patient is diagnosed with glucocerebroside lipidosis (Gaucher’s disease) that manifests as splenomegaly, liver enlargement, affected bone tissue, and neuropathies. What enzyme of complex lipid catabolism is deficient, thus causing this disease?
- A. Glucocerebrosidase
- B. Hyaluronidase
- C. Sphingomyelinase
- D. β-galactosidase
- E. Hexosaminidase
Hint
Ask which lysosomal hydrolase would normally cleave the sugar from the lipid that the stem names as accumulating, and which other storage diseases involve different lipids and enzymes.
The answer, the explanation and a note on every option are available once you log in. The account is free: topic tests, a mock exam, mistake review and statistics.
More questions on Biological Chemistry
- A 3-year-old girl with mental retardation has been diagnosed with sphingomyelin lipidosis (Niemann-Pick disease). In this condition the synthesis of…
- A 7-year-old child presents with marked signs of hemolytic anemia. Biochemical analysis of erythrocytes determined low concentration of NADPH and…
- An 8-year-old girl presents with signs of disturbed twilight vision. This condition is caused by the deficiency of vitamin:
- A 25-year-old young man came to the doctor complaining of general weakness, rapid fatigability, irritability, reduced working ability, and bleeding…
- A 52-year-old man presents with fever and pain in the joints. Both of his first metatarsophalangeal articulations are deformed, swollen, and…
- A patient, who has been subsisting exclusively on polished rice, has developed polyneuritis due to thiamine deficiency. What substance is an…