KROK 1 2018 – Question 175 · KROK (Medicine) · Biological Chemistry
A 7-year-old child presents with marked signs of hemolytic anemia. Biochemical analysis of erythrocytes determined low concentration of NADPH and reduced glutathione. What enzyme is deficient in this case leading to the biochemical changes and their clinical manifestations?
- A. Pyruvate kinase
- B. Glucose-6-phosphate dehydrogenase
- C. Fructokinase
- D. Lactate dehydrogenase
- E. Hexokinase
Hint
Ask which metabolic route supplies red cells with NADPH, and what happens to hemoglobin and the membrane when that supply fails.
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