KROK 1 2018 – Question 179 · KROK (Medicine) · Biological Chemistry
A 52-year-old man presents with fever and pain in the joints. Both of his first metatarsophalangeal articulations are deformed, swollen, and reddened. Blood urea is high. The patient is diagnosed with gout. What is the main developmental factor in the pathogenesis of this disease?
- A. Argininosuccinic aciduria
- B. Citrullinuria
- C. Hyperazotemia
- D. Hyperaminoacidemia
- E. Hyperuricemy
Hint
Gout is a crystal disease of joints; ask which metabolic pathway forms the crystal-producing substance and how its blood level must change for it to deposit in tissues.
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