KROK 1 2018 – Question 158 · KROK (Medicine) · Biological Chemistry
Congenital pyruvate carboxylase deficiency causes physical and mental retardation in children and leads to early death. It is characterized by lactic acidemia, lactaciduria, and a number of metabolic disorders. Among others, inhibition of the following occurs:
- A. Pentose-phosphate pathway and glycolysis
- B. Glycolysis and glycogenolysis
- C. Citric acid cycle and gluconeogenesis
- D. Glycogenesis and glycogenolysis
- E. Lipolysis and lipogenesis
Hint
Ask what product the enzyme makes from pyruvate and which two pathways depend on that product; the lactate in blood and urine shows where pyruvate goes instead.
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