KROK 1 2015 – Question 55 · KROK (Medicine) · Biological Chemistry
A patient has been diagnosed with alkaptonuria. Choose an enzyme that can cause this pathology when deficient:
- A. Homogentisic acid oxidase
- B. Dioxyphenylalanine decarboxylase
- C. Phenylalanine hydroxylase
- D. Glutamate dehydrogenase
- E. Pyruvate dehydrogenase
Hint
Recall the catabolic pathway of an aromatic amino acid that is interrupted in this inherited disorder, and the step at which an intermediate piles up and is excreted.
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