KROK 1 2014 – Question 182 · KROK (Medicine) · Biological Chemistry

A 28-year-old patient undergoing treatment in the pulmonological department has been diagnosed with pulmonary emphysema caused by splitting of alveolar septum by tissular trypsin. The disease is caused by the congenital deficiency of the following protein:

  1. A. α1-proteinase inhibitor
  2. B. Transferrin
  3. C. Haptoglobin
  4. D. α2-macroglobulin
  5. E. Cryoglobulin
Hint

Consider which circulating protein protects lung connective tissue from digestion by proteolytic enzymes, and why a young patient points to a congenital cause.

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