KROK 1 2014 – Question 179 · KROK (Medicine) · Biological Chemistry
A child has a history of hepatomegaly, hypoglycemia, seizures, especially on an empty stomach and in stressful situations. The child is diagnosed with Gierke disease. This disease is caused by the genetic defect of the following enzyme:
- A. Glucokinase
- B. Glucose-6-phosphatase
- C. Glycogen phosphorylase
- D. Amylo-1,6-glycosidase
- E. Phosphoglucomutase
Hint
Recall the biochemical block in this named glycogen storage disease and why it causes fasting hypoglycaemia together with an enlarged liver.
The answer, the explanation and a note on every option are available once you log in. The account is free: topic tests, a mock exam, mistake review and statistics.
More questions on Biological Chemistry
- A 28-year-old patient undergoing treatment in the pulmonological department has been diagnosed with pulmonary emphysema caused by splitting of…
- A patient with signs of osteoporosis and urolithiasis has been admitted to the endocrinology department. Blood test has revealed hypercalcemia and…
- In cancer patients who have been continuously receiving methotrexate, the target cells of tumor with time become insensitive to this drug. In this…
- Pancreas is known as a mixed gland. Endocrine functions include production of insulin by beta cells. This hormone affects the metabolism of…
- Characteristic sign of glycogenosis is muscle pain during physical work. Blood examination usually reveals hypoglycemia. This pathology is caused by…
- A 46-year-old female patient has continuous history of progressive muscular (Duchenne’s) dystrophy. Which blood enzyme changes will be of diagnostic…