KROK 1 2014 – Question 196 · KROK (Medicine) · Biological Chemistry
Pancreas is known as a mixed gland. Endocrine functions include production of insulin by beta cells. This hormone affects the metabolism of carbohydrates. What is its effect upon the activity of glycogen phosphorylase (GP) and glycogen synthase (GS)?
- A. It activates both GP and GS
- B. It does not affect the activity of GP and GS
- C. It activates GP and inhibits GS
- D. It inhibits GP and activates GS
- E. It inhibits both GP and GS
Hint
Think about whether insulin, as an anabolic hormone, favours storage or breakdown of glycogen, and how it changes the phosphorylation state of each enzyme.
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