KROK 1 2014 – Question 65 · KROK (Medicine) · Biological Chemistry

A 39-year-old female patient with a history of diabetes was hospitalized in a precomatose state for diabetic ketoacidosis. This condition had been caused by an increase in the following metabolite level:

  1. A. Citrate
  2. B. Aspartate
  3. C. Acetoacetate
  4. D. Malonate
  5. E. Alpha-ketoglutarate
Hint

Think about what lack of insulin does to fat breakdown, and what the liver makes from the excess acetyl units when oxaloacetate is scarce.

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