KROK 1 2008 – Question 26 · KROK (Medicine) · Pathophysiology

A 62 year woman complains of frequent pain attacks in the area of her chest and backbone, rib fractures. Her doctor suspected myeloma (plasmocytoma). What of the following laboratory characteristics will be of the greatest diagnostic importance?

  1. A. Hypoproteinemia
  2. B. Hypoglobulinemia
  3. C. Proteinuria
  4. D. Paraproteinemia
  5. E. Hyperalbuminemia
Hint

Plasma cells make immunoglobulins. Ask what appears in the serum when one malignant clone produces a single immunoglobulin in large amounts, and which finding is more specific than just a general rise in protein.

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