KROK 1 2008 – Question 56 · KROK (Medicine) · Pathophysiology

An animal with aortic valve insufficiency got hypertrophy of its left heart ventricle. Some of its parts have local contractures. What substance accumulated in the myocardiocytes caused these contractures?

  1. A. Potassium
  2. B. Carbon dioxide
  3. C. Calcium
  4. D. Lactic acid
  5. E. Sodium
Hint

Think about which ion is normally pumped out of the cytoplasm so fibres can relax, and which, if it builds up in overloaded cells, keeps contractile proteins locked.

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