KROK 1 2023 – Question 10 · KROK (Medicine) · Biological Chemistry
A 15-year-old patient complains of general weakness, dizziness, and rapid fatigability. Examination detects changed shape of erythrocytes and reduced erythrocyte count. A provisional diagnosis of sickle cell anemia was made. What amino acid replacement occurs in hemoglobin, causing the development of this pathological condition?
- A. Valine becomes replaced with aspartate
- B. Glutamate becomes replaced with aspartate
- C. Glutamate becomes replaced with valine
- D. Valine becomes replaced with glutamate
- E. Glutamate becomes replaced with alanine
Hint
Think about the point mutation in codon 6 of the β-globin gene and the change in charge and hydrophobicity it causes at the surface of haemoglobin.
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