KROK 1 2019 – Question 165 · KROK (Medicine) · Pathophysiology
A 45-year-old woman comes to her physician with complaints of excessive fatigue and weakness. She says that these symptoms have been present for the past month. On further questioning, she admits having lost 3 kilograms in the last 2 weeks. On physical examination, she is a tired-appearing thin woman. Hyperpigmentation is present over many areas of her body, most prominently over the face, neck and back of hands (areas exposed to light). Increased production of which of the following hormones is the most likely cause of hyperpigmentation in this patient?
- A. Melanocyte-stimulating hormone (MSH)
- B. β-Lipotropin
- C. Growth hormone (GH)
- D. Gonadotropins
- E. Thyroid-stimulating hormone (TSH)
Hint
Consider what loss of negative feedback does to the pituitary precursor molecule that is cleaved into several active products, and which product acts on pigment-producing cells.
The answer, the explanation and a note on every option are available once you log in. The account is free: topic tests, a mock exam, mistake review and statistics.
More questions on Pathophysiology
- A 38-year-old woman, who was diagnosed with systemic lupus erythematosus (SLE) 3 years ago, comes to her physician with a complaint of facial…
- A 54-year-old woman has a total thyroidectomy for papillary thyroid carcinoma. 11 hours after operation she complains of tingling around her mouth…
- An 11-year-old girl is brought to the doctor’s office by her mother who states her daughter has been weak with swollen face for 3 days. The mother…
- A male neonate born to a 24-year-old primigravida had jaundice at 8 hours of life. The neonate’s red blood cell type was A+, while the mother’s RBC…
- A 34-year-old man visits his dentist complaining of toothache. After a dental procedure that involved extraction of several teeth, he develops…
- A 47-year-old man complains of weakness and dizziness. Half a year ago he underwent a gastric resection. Blood test: Hb - 80 g/L, erythrocytes…