KROK 1 2019 – Question 157 · KROK (Medicine) · Pathophysiology
A 16-year-old girl concerned about her sexual development comes to the physician. She mentions that she has still not had a menstrual period. However, she is otherwise a healthy girl with no significant medical problems since birth. On physical examination, her vital signs are stable. She does not have pubic hair and her breast is slightly elevated with areola remaining in contour with surrounding breast. Which of the following is the most likely cause of this abnormal physical development?
- A. Hyperthyroidism
- B. Pancreatic islet insufficiency
- C. Ovarian insufficiency
- D. Hypothyroidism
- E. Adrenal medulla hyperfunction
Hint
Ask which endocrine organ's secretion normally drives breast development and the onset of menses, and whether anything else in the history suggests a systemic illness.
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