KROK 1 2019 – Question 176 · KROK (Medicine) · Pathophysiology
A male neonate born to a 24-year-old primigravida had jaundice at 8 hours of life. The neonate’s red blood cell type was A+, while the mother’s RBC type was 0+. Laboratory studies revealed elevated titer of mother’s anti-A antibody, normal erythrocyte glucose-6-phosphate and negative sickle cell test. The infant’s hemoglobin was 106 g/L. Which of the following is the most likely cause of infant’s jaundice?
- A. Decrease in hemoglobin level
- B. Rh incompatibility
- C. Hyperbilirubinemia
- D. Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- E. Sickle cell disease
Hint
Compare the blood groups of mother and baby and think about what jaundice within hours of birth says about red cell breakdown and the pigment it releases.
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