KROK 1 2018 – Question 43 · KROK (Medicine) · Pharmacology

A patient used an indirect-acting adrenergic agonist to treat rhinitis. After the patient has been putting in the nose drops for several days, the vasoconstrictive effect of the drug gradually diminished. Name this phenomenon:

  1. A. Cumulation
  2. B. Tachyphylaxis
  3. C. Teratogenicity
  4. D. Idiosyncrasy
  5. E. Allergy
Hint

Think about what happens to the stored mediator that an indirect sympathomimetic releases when the drug is given repeatedly at short intervals.

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