KROK 1 2016 – Question 173 · KROK (Medicine) · Biological Chemistry
Fructosuria is known to be connected with inherited deficiency of fructose 1-phosphate aldolase. What product of fructose metabolism will accumulate in the organism resulting in toxic action?
- A. Fructose 1-phosphate
- B. Glucose 1-phosphate
- C. Glucose 6-phosphate
- D. Fructose 6-phosphate
- E. Fructose 1,6-biphosphate
Hint
A metabolite builds up just upstream of an enzyme block: identify the substrate of the enzyme named in the stem and ask why trapping it inside cells would be toxic.
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