KROK 1 2016 – Question 171 · KROK (Medicine) · Biological Chemistry

Pancreas is known as a mixed gland. Endocrine functions include production of insulin by beta cells. This hormone affects metabolism of carbohydrates. What is its effect on the activity of glycogen phosphorylase (GP) and glycogen synthase (GS)?

  1. A. It inhibits both GP and GS
  2. B. It does not affect the activity of GP and GS
  3. C. It activates both GP and GS
  4. D. It activates GP and inhibits GS
  5. E. It inhibits GP and activates GS
Hint

Insulin signals the fed state: decide whether the liver and muscle should be storing or releasing glucose, and how dephosphorylation would change each enzyme.

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