KROK 1 2013 – Question 200 · KROK (Medicine) · Biological Chemistry
A 12-year-old patient was found to have blood serum cholesterol at the rate of 25 mmol/l. The boy has a history of hereditary familial hypercholesterolemia, which is caused by the impaired synthesis of the following protein receptors:
- A. High density lipoproteins
- B. Very low density lipoproteins
- C. Intermediate density lipoproteins
- D. Chylomicrons
- E. Low density lipoproteins
Hint
Consider the logic of a receptor defect: the ligand that cannot be taken up piles up in plasma, so identify which plasma particle class is cleared this way when cholesterol reaches 25 mmol/l.
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