KROK 1 2012 – Question 95 · KROK (Medicine) · Biological Chemistry
To prevent postoperative bleeding a 6-year-old child was administered vicasol that is a synthetic analogue of vitamin K. Name post-translational changes of blood coagulation factors that will be activated by vicasol:
- A. Carboxylation of glutamic acid
- B. Partial proteolysis
- C. Phosphorylation of serine radicals
- D. Glycosylation
- E. Polymerization
Hint
Recall the vitamin K-dependent modification of liver-made clotting factors that lets them bind calcium and anchor to phospholipid surfaces; ask which residue is changed and how.
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