KROK 1 2012 – Question 139 · KROK (Medicine) · Biological Chemistry
Osteolaterism is characterized by a decrease in collagen strength caused by much less intensive formation of crosslinks in collagen fibrils. This phenomenon is caused by the low activity of the following enzyme:
- A. Monoamino-oxidase
- B. Lysyl oxidase
- C. Prolyl hydroxylase
- D. Lysyl hydroxylase
- E. Collagenase
Hint
Think about the order of collagen maturation and ask which enzyme acts at the stage where covalent bonds form between neighbouring molecules, and what cofactor it needs.
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