KROK 1 2012 – Question 106 · KROK (Medicine) · Biological Chemistry
A patient has been diagnosed with alkaptonuria. Choose an enzyme whose deficiency can be the reason for this pathology:
- A. Dioxyphenylalanine decarboxylase
- B. Homogentisic acid oxidase
- C. Glutamate dehydrogenase
- D. Pyruvate dehydrogenase
- E. Phenylalanine hydroxylase
Hint
Place alkaptonuria on the degradation pathway of an aromatic amino acid and ask which late step must be missing for an intermediate to accumulate, be excreted and darken on standing.
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