KROK 1 2012 – Question 56 · KROK (Medicine) · Pathophysiology
A patient suffering from chronic myeloleukemia has got the following symptoms of anemia: decreased number of erythrocytes and low haemoglobin concentration, oxyphilic and polychromatophilic normocytes, microcytes. What is the leading pathogenetic mechanism of anemia development?
- A. Chronic haemorrhage
- B. Intravascular hemolysis of erythrocytes
- C. Reduced synthesis of erythropoietin
- D. Substitution of haemoblast
- E. Deficiency of vitamin B12
Hint
Ask what a leukaemic clone does to normal haemopoietic tissue and which type of anaemia the red cell picture supports.
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