KROK 1 2012 – Question 64 · KROK (Medicine) · Pathophysiology

A 44 year old woman complains of general weakness, heart pain, significant increase of body weight. Objectively: moon face, hirsutism, AP is 165/100 mm Hg, height - 164 cm, weight - 103 kg; the fat is mostly accumulated on her neck, thoracic girdle, belly. What is the main pathogenetic mechanism of obesity?

  1. A. Increased insulin production
  2. B. Reduced glucagon production
  3. C. Increased mineralocorticoid production
  4. D. Increased production of glucocorticoids
  5. E. Reduced production of thyroid hormones
Hint

Look at the whole picture, not only the weight: which hormone excess accounts for the combination of moon face, hypertension, hirsutism and trunk fat?

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