KROK 1 2010 – Question 185 · KROK (Medicine) · Pathomorphology
A 50 year old man who was referred to the hospital for treatment of cervical lymphadenitis underwent test for individual sensitivity to penicillin. 30 seconds after he went hot all over, AP dropped down to 0 mm Hg that led to cardiac arrest. Resuscitation was unsuccessful. Autopsy results: acute venous plethora of internal organs; histological examination of skin (from the site of injection) revealed degranulation of mast cells (tissue basophils). Degranulation was also revealed in myocardium and lungs. What type of hypersensitivity reaction is it?
- A. Immunocomplex-mediated
- B. Anaphylactic
- C. Complement-mediated cytotoxic
- D. Delayed-type hypersensitivity
- E. -
Hint
Consider how quickly the collapse followed the injection, and what the degranulation of mast cells tells you about the immune mechanism.
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