KROK 1 2008 – Question 6 · KROK (Medicine) · Pharmacology
A 37 year old patient suffering from obliterating vascular endarteritis of lower limbs takes daily 60 microgram/kilogram of phenylin. Because of presentations of convulsive disorder (craniocerebral trauma in anamnesis) he was prescribed phenobarbital. Withholding this drug caused nasal hemorrhage. What is this complication connected with?
- A. Aliphatic hydroxylation of phenobarbital
- B. Conjugation of phenylin with glucuronic acid
- C. Inhibition of microsomal oxidation in liver caused by phenobarbital
- D. Induction of enzymes of microsomal oxidation in liver caused by phenobarbital
- E. Oxidative deamination of phenylin
Hint
Think about how a long-term barbiturate changes the liver's handling of the anticoagulant, and what happens to the anticoagulant's blood level when the barbiturate is stopped but the anticoagulant dose is left unchanged.
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