KROK 1 2021 – Question 96 · KROK (Medicine) · Pharmacology
A 35-year-old woman was taking acetylsalicylic acid to relieve the pain in her carious tooth. After a time, she noticed digestive disorders, stomach heaviness, and heartburn. Why does this drug aggravate the gastric condition?
- A. Blocks PDE of smooth muscles
- B. Inhibits the activity of COX-1 in the stomach
- C. Increases hydrochloric acid secretion
- D. Disrupts the microcirculation in the gastrointestinal mucosa
- E. Increases pepsin activity
Hint
Consider which locally formed mediators keep the stomach lining supplied with mucus and bicarbonate, and what happens when their synthesising enzyme is blocked.
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