KROK 1 2021 – Question 94 · KROK (Medicine) · Pharmacology
A 60-year-old man, who has a long history of angina pectoris, was along with coronarolytics prescribed acetylsalicylic acid to decrease the platelet aggregation. What is the mechanism of antiaggregant action of acetylsalicylic acid?
- A. Reduces phosphodiesterase activity
- B. Increases platelet adenylate cyclase activity
- C. Reduces cyclooxygenase activity
- D. Has a membrane-stabilizing effect
- E. Increases prostacyclin synthesis
Hint
Think about the pro-aggregatory mediator that platelets make from arachidonic acid, and how an irreversibly acting (acetylating) drug could stop its formation.
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