KROK 1 2023 – Question 148 · KROK (Medicine) · Microbiology, Virology, and Immunology
The mother complains that her 7-month-old child has recurrent bacterial infections, such as conjunctivitis, otitis, sinopulmonary infections, diarrhea, and skin infections. Examination detects reduced size of the child's tonsils and lymph nodes. In the blood, examination of serum immunoglobulins shows noticeably reduced levels of IgM, IgA, and IgE, IgG is less than 100 mg/dL. What disease can be characterized by these pathological changes?
- A. Wiskott-Aldrich syndrome
- B. DiGeorge syndrome
- C. Hereditary adenosine deaminase defect in T lymphocytes
- D. X-linked agammaglobulinemia (Bruton disease)
- E. Hypogammaglobulinemia
Hint
Recurrent bacterial infections from about six months of age, underdeveloped lymphoid tissue and low levels of all immunoglobulin classes suggest a defect in one lymphocyte lineage.
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