KROK 1 2020 – Question 20 · KROK (Medicine) · Pharmacology
A 40-year-old man with pulmonary tuberculosis was prescribed isoniazid. Prolonged taking of this drug can result in the development of the following vitamin deficiency:
- A. Folic acid
- B. Biotin
- C. Pyridoxine
- D. Cobalamin
- E. Thiamine
Hint
Think of the hydrazide group of isoniazid, which reacts with carbonyl groups, and ask which vitamin-derived coenzyme it would bind and inactivate.
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