KROK 1 2019 – Question 134 · KROK (Medicine) · Biological Chemistry
A 27-year-old patient presents with pathologic changes in the liver and brain. Blood plasma exhibits acute decrease in copper levels, while urine copper levels are elevated. The patient is diagnosed with Wilson disease. To confirm this diagnosis it is necessary to measure activity of the following enzyme in the patient’s blood serum:
- A. Xanthine oxidase
- B. Ceruloplasmin
- C. Carbonic anhydrase
- D. Leucine aminopeptidase
- E. Alcohol dehydrogenase
Hint
Think about the defect in hepatic copper handling in this disease and which serum marker of that pathway would be reduced.
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