KROK 1 2019 – Question 121 · KROK (Medicine) · Pharmacology

A patient has been taking bisacodyl for a long time to treat chronic constipation. However, several weeks later the aperient effect of the drug diminished. What is the possible cause of this?

  1. A. Functional cumulation
  2. B. Sensitization
  3. C. Drug dependence
  4. D. Material cumulation
  5. E. Acquired tolerance
Hint

Consider what the body's adaptation to repeated exposure does to the size of the response to an unchanged dose.

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