KROK 1 2019 – Question 139 · KROK (Medicine) · Pharmacology

A woman with polyarticular rheumatoid arthritis was prescribed a non-steroidal antiinflammatory drug - diclofenac sodium. After the patient has been taking it for some time, her concomitant disease exacerbated, which forced the doctor to cancel the prescription of this drug. What concomitant disease could necessitate cancellation of this drug prescription?

  1. A. Bronchial asthma
  2. B. Diabetes mellitus
  3. C. Essential hypertension
  4. D. Ischemic heart disease
  5. E. Ulcer disease
Hint

Think about which protective prostaglandin-dependent mechanism these drugs weaken, and which pre-existing condition that loss would worsen.

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