KROK 1 2019 – Question 153 · KROK (Medicine) · Pharmacology
A 56-year-old man presents for a checkup. The patient says he has to urinate quite frequently, but denies any dysuria or pain on urination. Past medical history is significant for diabetes mellitus type 2 and hypertension, both managed medically. Current medications are metformin, aspirin, rosuvastatin, captopril and furosemide. Laboratory findings are significant for the following: Glycated Hemoglobin (HbA1c) - 8.0%, Fasting Blood Glucose - 12 mmol/L. His doctor decides to add glibenclamide to the therapy. Which of the following is the most likely mechanism of this drug’s action?
- A. Facilitation of glucose absorption in the intestine
- B. Inhibition of insulin release
- C. Stimulation of glucose reuptake by the cell
- D. Stimulation of insulin release
- E. -
Hint
Ask which pancreatic cell and which membrane ion channel this class of oral glucose-lowering drug acts on, and what that does to hormone output.
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