KROK 1 2017 – Question 80 · KROK (Medicine) · Microbiology, Virology, and Immunology
A 10-year-old child had cut his leg with a glass shard, when playing, and was delivered to the outpatient department to receive antitetanus serum. To prevent development of anaphylactic shock the serum was introduced by Bezredka method. This method of organism hyposensitization is based on the following mechanism:
- A. Blocking of mast cell mediators synthesis
- B. Stabilization of mast cell membranes
- C. Stimulation of immune tolerance to antigen
- D. Stimulation of antigen-specific IgG2
- E. Binding of mast cell-fixed IgE
Hint
Compare what a small first dose and one large dose of serum would each do in a sensitized person, and whether the mediators are then released all at once or in harmless portions.
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