KROK 1 2017 – Question 24 · KROK (Medicine) · Biological Chemistry
A child with point mutation presents with absence of glucose 6-phosphatase, hypoglycemia, and hepatomegaly. What pathology are these signs characteristic of?
- A. McArdle’s disease (Glycogen storage disease type V)
- B. Von Gierke’s disease (Glycogen storage disease type I)
- C. Addison’s disease (Primary adrenal insufficiency)
- D. Cori’s disease (Glycogen storage disease type III)
- E. Parkinson’s disease
Hint
Think about the final step that lets the liver release free glucose into the blood, and what accumulates in hepatocytes and happens to fasting blood sugar when that step is blocked.
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