KROK 1 2015 – Question 115 · KROK (Medicine) · Pathomorphology
A 65-year-old man suddenly lost vision in one eye due to the retinal detachment. The patient underwent enucleation. Histological examination of the removed eye retina and choroid revealed clusters of atypical cells with marked polymorphism of cells and nuclei, with a moderate number of mitoses including the pathological ones. The cell cytoplasm and intercellular medium contained brown pigment resulting in positive DOPA reaction. Perls’ reaction was negative. What is the most likely diagnosis?
- A. Wilson’s disease
- B. Cysticercosis
- C. Melanoma
- D. Hemorrhage
- E. Pigmented mole
Hint
Use the positive DOPA reaction to identify the pigment, the negative Perls reaction to exclude another pigment, and the atypia with pathological mitoses to judge whether the process is benign.
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