KROK 1 2014 – Question 143 · KROK (Medicine) · Pathomorphology

An HIV-positive patient’s cause of death is acute pulmonary insufficiency resulting from pneumonia. Pathohistological investigation of lungs has revealed interstitial pneumonia, alveolocyte desquamation and their metamorphoses: alveolocyte enlargement, large intranuclear inclusions surrounded by lightly colored areas. Transformed cells resemble owl’s eye. Name the pneumonia causative agent:

  1. A. Cytomegalovirus
  2. B. Influenza virus
  3. C. Pneumococcus
  4. D. Candida fungi
  5. E. Toxoplasma
Hint

Intranuclear inclusions with a halo and cell enlargement are cytopathic changes; decide which class of opportunistic pathogen in advanced HIV infection produces them.

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