KROK 1 2014 – Question 142 · KROK (Medicine) · Pathomorphology

On the 24th day since the onset of disease, a male patient diagnosed with typhoid fever and undergoing treatment in an infectious diseases hospital has suddenly developed clinical presentations of acute abdomen leading to the death of the patient. During autopsy peritonitis has been revealed, with numerous ulcers covering the colon mucosa and reaching as deep as muscular and, in places, serous tunic. The ulcers have smooth edges and even floor. The intestinal wall is perforated. What stage of typhoid fever has the lethal complication arisen at?

  1. A. Clean ulcer
  2. B. Dirty ulcer
  3. C. Medullary swelling
  4. D. Regeneration
  5. E. Necrosis
Hint

Relate the day of the illness to the usual weekly sequence of morphological changes in the intestinal lymphoid tissue in this infection, and look at the appearance of the floor of the lesion.

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