KROK 1 2013 – Question 139 · KROK (Medicine) · Pathomorphology
A 65-year-old male suddenly lost the vision in one eye due to the retinal detachment. The patient underwent enucleation. Histological examination of the removed eye retina and choroid revealed clusters of atypical cells with marked polymorphism of cells and nuclei, with a moderate number of mitoses including the pathological ones. The cell cytoplasm and intercellular medium contained brown pigment giving a positive DOPA reaction. Perls’ reaction was negative. What is the most likely diagnosis?
- A. Wilson’s disease
- B. Pigmented mole
- C. Hemorrhage
- D. Cysticercosis
- E. Melanoma
Hint
Combine the DOPA-positive pigment, the negative iron stain and the atypical cells with pathological mitoses to decide what the pigment is and whether the process is benign.
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