KROK 1 2013 – Question 100 · KROK (Medicine) · Biological Chemistry
It is known that the monoamine oxidase (MAO) enzyme plays an important part in the metabolism of catecholamine neurotransmitters. In what way does the enzyme inactivate these neurotransmitters (norepinephrine, epinephrine, dopamine)?
- A. Addition of an amino group
- B. Removal of a methyl group
- C. Hydrolysis
- D. Carboxylation
- E. Oxidative deamination
Hint
Think about the cofactor and location of monoamine oxidase (FAD-dependent, outer mitochondrial membrane) and which part of the catecholamine molecule is lost when it acts.
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