KROK 1 2013 – Question 98 · KROK (Medicine) · Biological Chemistry
An unconscious patient was taken by ambulance to the hospital. On objective examination the patient was found to have no reflexes, periodical convulsions, irregular breathing. After laboratory examination the patient was diagnosed with hepatic coma. Disorders of the central nervous system develop due to the accumulation of the following metabolite:
- A. Ammonia
- B. Histamine
- C. Bilirubin
- D. Glutamine
- E. Urea
Hint
Ask which nitrogenous product, normally cleared by the liver's detoxification cycle, accumulates when the liver fails and then poisons brain metabolism.
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