KROK 1 2013 – Question 11 · KROK (Medicine) · Pharmacology

A 60-year-old patient with a long history of stenocardia takes coronarodilator agents. He has also been administered acetylsalicylic acid to reduce platelet aggregation. What is the mechanism of antiplatelet action of acetylsalicylic acid?

  1. A. It has membrane stabilizing effect
  2. B. It enhances the activity of platelet adenylate cyclase
  3. C. It reduces the activity of cyclooxygenase
  4. D. It reduces the activity of phosphodiesterase
  5. E. It enhances the synthesis of prostacyclin
Hint

Ask which platelet-derived mediator promotes aggregation and which step in its synthesis this drug could block.

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