KROK 1 2013 – Question 2 · KROK (Medicine) · Pharmacology

A 60-year-old male patient has a 9-year history of diabetes and takes insulin Semilente for the correction of hyperglycemia. 10 days ago he began taking anaprilin for hypertension. One hour after administration of the antihypertensive drug the patient developed hypoglycemic coma. What is the mechanism of hypoglycemia in case of anaprilin use?

  1. A. Increase of insulin Semilente half-life
  2. B. Inhibition of glycogenolysis
  3. C. Increase of bioavailability of insulin Semilente
  4. D. Reduction of glucagon half-life
  5. E. Decrease in glucose absorption
Hint

Think about how the body normally counters insulin-induced hypoglycaemia and which receptor-dependent step anaprilin could disturb.

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