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Question 51 (part 2) · LEK · Gastrointestinal stromal tumors (GIST)

Which is true about gastrointestinal stromal tumours (GIST)?

  1. A. they are typically asymptomatic, although the larger ones may trigger dyspepsia, ulceration and bleeding from the digestive tract, unlike other mesenchymal neoplasms they do not show proto-oncogene c-kit expression.
  2. B. those of a diameter < 2cm typically manifest as gastrointestinal bleeding, unlike other mesenchymal neoplasms they do not show proto-oncogene c-kit expression.
  3. C. they are typically asymptomatic, although the larger ones may trigger dyspepsia, ulceration and bleeding from the digestive tract, they show proto-oncogene c-kit expression.
  4. D. those of a diameter < 2cm typically manifest as gastrointestinal bleeding, unlike other mesenchymal neoplasms they show proto-oncogene c-kit expression.
  5. E. they are benign and never become malignant, but due to the strong tendency to cause ulceration they require treatment with a tyrosine kinase inhibitor.
Hint

Recall the immunohistochemical marker (CD117) used to diagnose GIST and how small tumours usually come to attention.

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