Question 66 (part 2) · LEK · Gastric cancer

Selected characteristics of gastric cancers according to Lauren classification are given below. Which of them describe intestinal type adenocarcinoma best?

  1. A. a prepyloric location, a connection with Helicobacter pylori infection, blood metastases to the liver.
  2. B. location at the angular incisure, a connection with e-cadherin-coding gene mutations, infiltration of the peritoneum in continuity.
  3. C. location in the body of the stomach, a connection with e-cadherin-coding gene mutations, an exophytic tumour, well-demarcated .
  4. D. location in the body of the stomach, increased risk with alcohol consumption and smoking, infiltration in continuity.
  5. E. a prepyloric location, thickening of the gastric wall with mucosal ulceration, no possibility of surgical treatment even in the early stages.
Hint

The intestinal type develops through the gastritis–atrophy–metaplasia sequence; think about its cause and how it spreads.

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