Question 354 · LEK · Granulomatosis with polyangiitis

A 32-year-old man running a fever of up to 40 °C visited his doctor. The physical examination revealed otitis media and pneumonia of the right lung confirmed with an X-ray. Laboratory tests showed proteinuria and erythrocyturia with predominance of dysmorphic erythrocytes. Which of the following tests should be performed to confirm the probable diagnosis?

  1. A. ear swab.
  2. B. ANA.
  3. C. antibodies against Chlamydia trachomatis.
  4. D. antibodies against Jo-1.
  5. E. ANCA.
Hint

Combine upper airway, lung and glomerular involvement into one systemic disease and choose its serological marker.

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