Question 334 · LEK · Hepatocellular carcinoma (HCC)

A 58-year-old male presents at the outpatient unit due to focal lesion of 3 cm in diameter in the left liver lobe, accidentally detected during abdominal ultrasound. In history: chronic hepatitis B, moderate alcohol consumption, no systemic symptoms. Laboratory tests revealed normal ALT/AST and elevated AFP (alpha-fetoprotein) levels. Indicate the appropriate management:

  1. A. immediate percutaneous biopsy of the liver tumour under ultrasound guidance.
  2. B. CT or MRI scan with contrast enhancement.
  3. C. observation and repeat ultrasound scan with elastography in 12 months.
  4. D. initiation of empirical chemotherapy.
  5. E. surgical treatment without further diagnostics.
Hint

In a high-risk liver, HCC can often be diagnosed non-invasively; what study shows the typical vascular pattern of the lesion?

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