KROK 1 2007 – Question 43 · KROK (Medicine) · Biological Chemistry
A child is languid, apathetic. Liver is enlarged and liver biopsy revealed a significant excess of glycogene. Glucose concentration in the blood stream is below normal. What is the cause of low glucose concentration?
- A. Low (absent) activity of glucose 6-phosphatase
- B. Deficit of a gene that is responsible for synthesis of glucose 1-phosphaturidine transferase
- C. Low (absent) activity of hexokinase
- D. High activity of glycogen synthetase
- E. Low (absent) activity of glycogene phosphorylase in liver
Hint
Consider the first enzymatic step that releases glucose units from stored liver glycogen during fasting, and what accumulates when that step is missing.
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