KROK 1 2008 – Question 188 · KROK (Medicine) · Biological Chemistry
Plasmic factors of blood coagulation are exposed to post-translational modification with the participation of vitamin K. It is necessary as a cofactor in the enzyme system of γ-carboxylation of protein factors of blood coagulation due to the increased affinity of their molecules with calcium ions. What amino acid is carboxylated in these proteins?
- A. Glutamic
- B. Valine
- C. Arginine
- D. Serine
- E. Phenylalanine
Hint
Calcium binding needs negatively charged groups; ask which of the listed amino acids has a side chain that could carry such a group, and which are hydrophobic, basic or hydroxylated.
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